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Nucleofill Skin Booster

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Nucleofill: Your Guide to Skin-Lifting Injectable Treatment with Active Polynucleotides

What is Nucleofill?

Nucleofill is a non-surgical treatment designed to Repair, Regenerate and Lift the skin. It utilises active High Concentration Polynucleotides from Salmon DNA to stimulate collagen production and enhance skin elasticity. This treatment aims to restore youthful contours and improve overall skin texture, making it a sought-after solution for those looking to combat signs of ageing.




How Does Nucleofill Work?

Nucleofill’s working mechanism is rooted in the science of High Concentration Polynucleotides. Once injected, these active molecules stimulate fibroblasts, which are responsible for collagen production. The increased collagen helps plump and tighten the skin, reducing the appearance of fine lines and wrinkles. The treatment also aids in skin hydration and improves overall skin quality.

Nucleofill operates as a biostimulator, a category of biocompatible synthetic substances compatible with the human body. These substances effectively stimulate fibroblasts, the collagen-producing cells within the dermis. This stimulation results in increased production of collagen and elastin, leading to skin tightening and lifting.

Beyond addressing ageing-related issues like sagging, fine lines, wrinkles, and skin dehydration, Nucleofill is a versatile treatment that can also rectify skin dehydration, mitigate oxidative stress, treat scars (such as those from chickenpox or acne), and even target stretch marks.

Benefits of Nucleofill

Nucleofill offers a range of benefits, including:

  • Skin Tightening and Lifting.

  • Reduction of fine lines and Wrinkles.

  • Skin Radiance and Glow.

  • Smoothen skin Texture and Elasticity.

  • Skin Repair and Regeneration.

  • Minimal downtime and discomfort.
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What results can Nucleofill achieve?

Nucleofill is a treatment option that is also known as “skin bioregeneration”. It aims to achieve 3 key outcomes through a single High Concentration Polynucleotide injection: 

-Skin Lifting / Tightening
-Skin Hydration


Skin Lifting

Nucleofill employs bio-engineered polynucleotides to engage surface receptors on dermal fibroblast cells. This engagement prompts the activation of myofibroblast cells, which are responsible for producing type I collagen and elastin. These newly produced collagen and elastin help firm and elevate the skin, effectively reducing sagging and smoothing out wrinkles. By restructuring the dermal matrix with fresh collagen and elastin, Nucleofill addresses the root cause of skin laxity, resulting in enduring and profound skin rejuvenation.

Antioxidant Properties

Over time, free radicals can harm and break down skin cells, including collagen fibers, leading to the degradation of skin structure, a loss of elasticity, wrinkle formation, and changes in skin texture. Nucleofill acts as a free radical scavenger, effectively removing free radicals. Its potent antioxidant capabilities safeguard collagen fibers, rejuvenate skin, and the epidermis against further damage caused by free radicals.


At the core of Nucleofill lies polynucleotides, which exhibit a strong affinity for binding with water. This binding between polynucleotides and water molecules within the dermal matrix ensures deep and long-lasting skin hydration. This process, known as hydrolifting, imparts a firm and moisturized sensation to the skin.

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Who Should Consider Nucleofill?

Nucleofill is suitable for individuals looking to address signs of aging, such as skin laxity, wrinkles, and “crepey” skin. It is an excellent option for those who seek a non-invasive treatment with noticeable, long-lasting results.

-Skin lacking moisture and radiance.

-Reduced skin firmness and resilience coupled with inadequate blood circulation.

-Skin that has endured oxidative damage.

-Noticeable indications of aging, such as skin laxity.

-Individuals desiring enhanced firmness, better contours, and increased definition.

-Scar-related issues.

-Bio-stimulation and an upsurge in type 1 collagen.

-Stretch marks.

Consult with us to determine if Nucleofill is right for you.


What Sets Nucleofill Apart?

What distinguishes Nucleofill is the use of High Concentration active Polynucleotides. These molecules, extracted from Salmon DNA, possess effective regenerative properties. When introduced into the skin, they trigger collagen synthesis, leading to improved skin firmness and texture.



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How is Nucleofill administered?

Nucleofill treatment necessitates the administration of injections at five specific points on each side of the face. These points are strategically chosen due to their minimal risk of interfering with blood vessels or nerves in the treated regions.

The procedure is typically comfortable, involving minimal to no downtime. Some patients may experience mild sensations of pinching and skin stretching during the treatment, which are generally tolerable. For those who have a low pain threshold, numbing cream can be provided to enhance comfort during the procedure.


What Happens During Nucleofill Treatment?

During a Nucleofill session, the polynucleotides contained in Nucleofill offer a dual bio-stimulatory impact:

1. They trigger fibroblasts to enhance the production of type I collagen and elastin, ultimately improving skin quality.

2. They contribute to the transformation of fibroblasts into myofibroblasts, resulting in a skin-tightening and reinforcing effect.

Hydration and Antioxidant Effect:

1. Polynucleotides operate within the dermal matrix by binding to water molecules, delivering prolonged hydration.

2. Nucleofill boasts potent antioxidant characteristics, which play a crucial role in eliminating free radicals and preserving the skin from further harm.

Why Choose M-Aesthetic Clinic?

Years of Experience

Trusted by Patients

Proven Results

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Consult M-Aesthetic Clinic for Nucleofill Skin Booster for a more radiant skin in Singapore

If you’re considering Nucleofill Skin Booster in Singapore, M-Aesthetic Clinic is your trusted partner for achieving your desired skin goals. 

Enhance your skin’s radiance with Nucleofill Skin Booster by consulting M-Aesthetic Clinic in Singapore. Discover the rejuvenating benefits of this treatment, tailored to revitalise and revamp your skin, giving you a more radiant and youthful appearance.

Frequently Asked Questions ABOUT Nucleofill

Is Nucleofill a safe treatment?

Yes, Nucleofill is considered safe when administered by a qualified and experienced medical practitioner. It utilizes active polynucleotides extracted from salmon DNA, which are biocompatible and pose minimal risk of allergic reactions.

How long do the results of Nucleofill last?

The results of Nucleofill are long-lasting, typically last up to 12 months. However, the duration may vary from person to person, depending on factors like individual metabolism and the treated area.

What areas can be treated with Nucleofill?

Nucleofill is versatile and can be used to treat various areas, including the face, neck, décolletage, and hands. It’s particularly effective in addressing sagging skin, fine lines, and wrinkles.

What is the recovery process like after Nucleofill treatment?

Nucleofill typically has minimal to NO downtime. Some patients may experience minor redness, swelling, or bruising at the injection sites, but these side effects usually resolve within a few days. Patients can often resume their regular activities immediately after the procedure.

Are there any side effects associated with Nucleofill?

Nucleofill is known for its safety and minimal side effects. Common side effects may include mild redness, swelling, or bruising at the injection sites, which are temporary and generally subside within a short time.

How soon will I see results after Nucleofill treatment?

Many patients notice an improvement in their skin’s tightness and texture shortly after the treatment. However, the full results may become more apparent over the course of several weeks as the active polynucleotides stimulate collagen production.

Can Nucleofill be combined with other treatments?

Nucleofill can be combined with other aesthetic treatments to enhance overall results. Combining Nucleofill with procedures like dermal fillers or Botox is a popular choice to address multiple aspects of skin ageing.

Contact Us




M-Aesthetic Clinic

Novena Medical Center,
#11-07/08, 10 Sinaran Drive
Singapore 307506

Weekdays: 11am – 8pm
Saturdays: 10am – 3pm
Sundays: Closed
Call | Whatsapp: +65 8129 9120
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